Since 2001, four long-term studies have examined the utility of glucosamine and/or chondroitin supplementation versus placebo in patients suffering from osteoarthritis (OA) of the knee ^(1-4). One long-term study compared glucosamine sulfate with placebo in patients with OA of the hip ⁽⁵⁾. To date, there has yet to be a trial with glucosamine/chondroitin for spinal OA, although one case history has been published ⁽⁶⁾.